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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
2015·9.355 Zitationen·New England Journal of MedicineOpen Access
Volltext beim Verlag öffnen9.355
Zitationen
35
Autoren
2015
Jahr
Abstract
This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab. (Funded by Johns Hopkins University and others; ClinicalTrials.gov number, NCT01876511.).
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Autoren
- Dung T. Le
- Jennifer N. Uram
- Hao Wang
- Bjarne R. Bartlett
- Holly Kemberling
- Aleksandra Eyring
- Andrew D. Skora
- Brandon Luber
- Nilofer S. Azad
- Dan Laheru
- Barbara Biedrzycki
- Ross C. Donehower
- Atif Zaheer
- George A. Fisher
- Todd S. Crocenzi
- James J. Lee
- Steven M. Duffy
- Richard M. Goldberg
- Albert de la Chapelle
- Minori Koshiji
- Feriyl Bhaijee
- Thomas Huebner
- Ralph H. Hruban
- Laura D. Wood
- Nathan Cuka
- Drew M. Pardoll
- Nickolas Papadopoulos
- Kenneth W. Kinzler
- Shibin Zhou
- Toby C. Cornish
- Janis M. Taube
- Robert A. Anders
- James R. Eshleman
- Bert Vogelstein
- Luis A. Díaz
Institutionen
- Sidney Kimmel Comprehensive Cancer Center(US)
- Swim Across America(US)
- Howard Hughes Medical Institute(US)
- Johns Hopkins University(US)
- Johns Hopkins Medicine(US)
- Stanford University(US)
- Providence Health & Services(US)
- UPMC Hillman Cancer Center(US)
- Virginia Cancer Institute(US)
- Cancer Genetics (United States)(US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute(US)
- Merck & Co., Inc., Rahway, NJ, USA (United States)(US)
Themen
Genetic factors in colorectal cancerCancer Immunotherapy and BiomarkersCancer Genomics and Diagnostics