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Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.
334
Zitationen
9
Autoren
2001
Jahr
Abstract
The fluoromethyl choline analog FCH may serve as a probe of choline uptake and phosphorylation in cancer cells, whereas fluoroethyl (FEC) and fluoropropyl (FPC) analogs appear to have relatively poorer biologic compatibility. Preliminary PET studies on patients with prostate cancer and with breast cancer and brain tumor support further studies to evaluate the usefulness of FCH as an oncologic probe.
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