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Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors
4.374
Zitationen
21
Autoren
2002
Jahr
Abstract
Imatinib induced a sustained objective response in more than half of patients with an advanced unresectable or metastatic gastrointestinal stromal tumor. Inhibition of the KIT signal-transduction pathway is a promising treatment for advanced gastrointestinal stromal tumors, which resist conventional chemotherapy.
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Autoren
- George D. Demetri
- Margaret von Mehren
- Charles D. Blanke
- Annick D. Van den Abbeele
- Burton Eisenberg
- Peter Roberts
- Michael C. Heinrich
- David A. Tuveson
- Samuel Singer
- Milos J. Janicek
- Jonathan A. Fletcher
- Stuart G. Silverman
- Sandra Silberman
- Renaud Capdeville
- Beate Kiese
- Bin Peng
- Saša Dimitrijević
- Brian Druker
- Christopher L. Corless
- Christopher D.�M. Fletcher
- Heikki Joensuu