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Recombinant human bone morphogenetic protein-2 use in the off-label treatment of nonunions and acute fractures
31
Zitationen
4
Autoren
2012
Jahr
Abstract
Off-label use of BMP-2 in acute fractures and nonunions resulted in a 66% success rate. It remains uncertain whether there is any clinical advantage to this approach, but it appears that female gender, open injury, and higher volumes of bone defect may be important negative prognostic factors for obtaining radiographic union. Appropriately powered prospective randomized trials are needed for further clarification, especially in light of the high cost of this treatment.
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