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Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography

1975·4.687 Zitationen·European Journal of Biochemistry
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4.687

Zitationen

2

Autoren

1975

Jahr

Abstract

Methods which use the scintillator PPO to record film images of 3H in chromatograms and polyacrylamide gels (fluorography) have been described elsewhere. This paper demonstrates that pre-exposure of the film to a brief flash of light greatly increases the sensitivity of fluorography. Pre-exposure also permits quantitative interpretation of the film image, because it corrects the non-linear relationship between radioactivity of the sample and absorbance of the film image. Therefore the distribution of radioactivity in the sample is accurately represented by microdensitometry of the image obtained on pre-exposed film. Using pre-exposed film 300 dis. 3H/min or 30 dis. 14C/min can be detected in a band in a gel in a 24-h exposure. The Appendix describes revisions and extensions of existing fluorographic procedures, including application to agarose gels and a rapid procedure for recovering PPO for re-use.

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Institutionen

Themen

Medical Imaging Techniques and ApplicationsMethane Hydrates and Related PhenomenaNuclear Physics and Applications
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