Dies ist eine Übersichtsseite mit Metadaten zu dieser wissenschaftlichen Arbeit. Der vollständige Artikel ist beim Verlag verfügbar.
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
13.684
Zitationen
2
Autoren
2002
Jahr
Abstract
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Abeta in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance.
Ähnliche Arbeiten
Clinical diagnosis of Alzheimer's disease
1984 · 27.891 Zit.
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 · 18.485 Zit.
Neuropathological stageing of Alzheimer-related changes
1991 · 16.035 Zit.
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 · 10.393 Zit.
The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 · 9.940 Zit.