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Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?
163
Zitationen
4
Autoren
2005
Jahr
Abstract
This study demonstrates that investigators evaluating aprotinin were not adequately citing previous research, resulting in a large number of RCTs being conducted to address efficacy questions that prior trials had already definitively answered. Institutional review boards and journals could reduce the number of redundant trials by requiring investigators to conduct adequate searches for prior evidence and conducting systematic reviews.
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