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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
8.026
Zitationen
31
Autoren
2015
Jahr
Abstract
Among previously untreated patients with metastatic melanoma, nivolumab alone or combined with ipilimumab resulted in significantly longer progression-free survival than ipilimumab alone. In patients with PD-L1-negative tumors, the combination of PD-1 and CTLA-4 blockade was more effective than either agent alone. (Funded by Bristol-Myers Squibb; CheckMate 067 ClinicalTrials.gov number, NCT01844505.).
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Autoren
- James Larkin
- Vanna Chiarion‐Sileni
- René González
- Jean‐Jacques Grob
- C. Lance Cowey
- Christopher D. Lao
- Dirk Schadendorf
- Reinhard Dummer
- Michael Smylie
- Piotr Rutkowski
- Pier Francesco Ferrucci
- Andrew Hill
- John Wagstaff
- Matteo S. Carlino
- John B.A.G. Haanen
- Michele Maio
- Iván Márquez‐Rodas
- Grant A. McArthur
- Paolo A. Ascierto
- Georgina V. Long
- Margaret K. Callahan
- Michael A. Postow
- Kenneth F. Grossmann
- Mario Sznol
- Brigitte Dréno
- Lars Bastholt
- Arvin Yang
- Linda M. Rollin
- Christine E. Horak
- F. Stephen Hodi
- Jedd D. Wolchok
Institutionen
- Royal Marsden Hospital(GB)
- University of Colorado Denver(US)
- Aix-Marseille Université(FR)
- The University of Sydney(AU)
- University of Michigan(US)
- University of Zurich(CH)
- University Hospital of Zurich(CH)
- The Maria Sklodowska-Curie National Research Institute of Oncology(PL)
- European Institute of Oncology(IT)
- Trans Tasman Radiation Oncology Group(AU)
- Singleton Hospital(GB)
- Melanoma Institute Australia(AU)
- Blacktown & Mount Druitt Hospital(AU)
- The Netherlands Cancer Institute(NL)
- University of Siena(IT)
- Hospital General Universitario Gregorio Marañón(ES)
- Peter MacCallum Cancer Centre(AU)
- The University of Melbourne(AU)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"(IT)
- Mater Hospital(GB)
- Memorial Sloan Kettering Cancer Center(US)
- Cornell University(US)
- University of Utah(US)
- Huntsman Cancer Institute(US)
- Yale New Haven Hospital(US)
- Yale University(US)
- Yale Cancer Center(US)
- Smilow Cancer Hospital(US)
- Hotel Dieu Hospital(CA)
- Odense University Hospital(DK)
- Bristol-Myers Squibb (United States)(US)
- Dana-Farber Cancer Institute(US)