Dies ist eine Übersichtsseite mit Metadaten zu dieser wissenschaftlichen Arbeit. Der vollständige Artikel ist beim Verlag verfügbar.
Fluorine (<sup>19</sup>F) MRS and MRI in biomedicine
478
Zitationen
4
Autoren
2010
Jahr
Abstract
Shortly after the introduction of (1)H MRI, fluorinated molecules were tested as MR-detectable tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically inert, are now being used in a broad range of biomedical applications, including anesthetics, chemotherapeutic agents, and molecules with high oxygen solubility for respiration and blood substitution. These compounds can be monitored by fluorine ((19)F) MRI and/or MRS, providing a noninvasive means to interrogate associated functions in biological systems. As a result of the lack of endogenous fluorine in living organisms, (19)F MRI of 'hotspots' of targeted fluorinated contrast agents has recently opened up new research avenues in molecular and cellular imaging. This includes the specific targeting and imaging of cellular surface epitopes, as well as MRI cell tracking of endogenous macrophages, injected immune cells and stem cell transplants.
Ähnliche Arbeiten
Advances in functional and structural MR image analysis and implementation as FSL
2004 · 14.031 Zit.
A default mode of brain function
2001 · 12.334 Zit.
FSL
2011 · 11.662 Zit.
Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images
2002 · 10.608 Zit.
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
1995 · 10.028 Zit.