The Efficacy of Recombinant Human Erythropoietins after Autologous Blood Collection in Patients Undergoing Two Jaw Surgery.

Abstract

The efficacy of recombinant human erythropoietin (Epo and Esp) was studied inpatients who underwent two jaw surgery for correction of jaw deformities after collection of 1200ml of autologous blood.The patients were classified into group A (7 patients) with administration of Fe alone, group B (12 patients) with Fe and Epo (9 times), group C (5 patients) with Fe and Esp (3 times) and group D (6 patients) with Fe and Esp (4 times) depending on the results of blood examination. Mean Hb, RBC and Ht before surgery in group A were 12.1g/dl, 401×104/μl and 35.9%, respectively. The decreases of these values before sugery were maximum in group A and yet the values were higher than those of the other groups. Despite significantly lower Hb and Ht before blood collection, mean Hb, RBC and Ht before surgery for groups B, C and D were 10.5-11.4g/dl. 354-386×104/μl and 32.0-34.7%, respectively and they showed good recovery after surgery. Among these groups, group C showed the poorest results.In conclusion, recombinant human erythropoietin, in particular Esp with a total of 4 injections, was most effective in restoring anemia after blood collection.

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