Why published research is untrustworthy

Abstract

As much as 90% of the published medical information is flawed according to John Ioannidis, one of the true experts on credibility of medical research [1], and former BMJ editorin-chief, Richard Smith, has claimed that Bmost of what is published in journals is just plain wrong or nonsense.^Thepoor quality of medical research is not a new criticism [2]; however, concern has been expressed within a broad field of specialties in parallel with reports that studies are fraught with problems including poor reproducibility [3].Publishing research is complex.It includes a wide range of steps and the interaction of many collaborators (coauthors, sponsors, editors, reviewers and peers), and this may contribute to problems including scientific misconduct, methodological issues/errors and bias (Table 1).

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