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Efficacy of Larotrectinib in <i>TRK</i> Fusion–Positive Cancers in Adults and Children
2.640
Zitationen
38
Autoren
2018
Jahr
Abstract
Larotrectinib had marked and durable antitumor activity in patients with TRK fusion-positive cancer, regardless of the age of the patient or of the tumor type. (Funded by Loxo Oncology and others; ClinicalTrials.gov numbers, NCT02122913 , NCT02637687 , and NCT02576431 .).
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Autoren
- Alexander Drilon
- Theodore W. Laetsch
- Shivaani Kummar
- Steven G. DuBois
- Ulrik Lassen
- George D. Demetri
- Michael J. Nathenson
- Robert C. Doebele
- Anna F. Farago
- Alberto S. Pappo
- Brian Turpin
- Afshin Dowlati
- Marcia S. Brose
- Leo Mascarenhas
- Noah Federman
- Jordan Berlin
- Wafik S. El‐Deiry
- Christina S. Baik
- John F. Deeken
- Valentina Boni
- Ramamoorthy Nagasubramanian
- Matthew H. Taylor
- Erin R. Rudzinski
- Funda Meric‐Bernstam
- Davendra Sohal
- C. Patrick
- Luis E. Raez
- Jaclyn F. Hechtman
- Ryma Benayed
- Marc Ladanyi
- Brian B. Tuch
- Kevin Ebata
- Scott Cruickshank
- Nora Ku
- Michael C. Cox
- Douglas S. Hawkins
- David S. Hong
- David M. Hyman
Institutionen
- Cornell University(US)
- Memorial Sloan Kettering Cancer Center(US)
- The University of Texas Southwestern Medical Center(US)
- Stanford University(US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center(US)
- Rigshospitalet(DK)
- Dana-Farber Cancer Institute(US)
- University of Colorado Anschutz Medical Campus(US)
- Massachusetts General Hospital(US)
- St. Jude Children's Research Hospital(US)
- Cincinnati Children's Hospital Medical Center(US)
- University Hospitals of Cleveland(US)
- Abramson Cancer Center
- University of Southern California(US)
- Children's Hospital of Los Angeles(US)
- Olive View-UCLA Medical Center(US)
- Vanderbilt University(US)
- Fox Chase Cancer Center(US)
- Seattle Cancer Care Alliance(US)
- University of Washington(US)
- South Texas Accelerated Research Therapeutics(US)
- Nemours Children's Clinic(US)
- Oregon Health & Science University(US)
- Seattle Children's Hospital(US)
- The University of Texas MD Anderson Cancer Center(US)
- Cleveland Clinic(US)
- West Virginia University(US)
- West Virginia State University(US)
- Florida International University(US)
- Florida Memorial University(US)
- Loxo Oncology at Lilly (United States)(US)
- Fred Hutch Cancer Center(US)
- Cancer Research Center(US)