Controversies, Consensus, and Collaboration in the Use of ¹³¹ I Therapy in Differentiated Thyroid Cancer: A Joint Statement from the American Thyroid Association, the European Association of Nuclear Medicine, the Society of Nuclear Medicine and Molecular Imaging, and the European Thyroid Association

Abstract

By fostering an open, productive, and evidence-based discussion, the Martinique meeting restored trust, confidence, and a sense of collegiality between individuals and organizations that are committed to optimal thyroid disease management. The result of this first meeting is a set of nine principles (The Martinique Principles) that (i) describe a commitment to proactive, purposeful, and inclusive interdisciplinary cooperation; (ii) define the goals of ¹³¹I therapy as remnant ablation, adjuvant treatment, or treatment of known disease; (iii) describe the importance of evaluating postoperative disease status and multiple other factors beyond clinicopathologic staging in ¹³¹I therapy decision making; (iv) recognize that the optimal administered activity of ¹³¹I adjuvant treatment cannot be definitely determined from the published literature; and (v) acknowledge that current definitions of ¹³¹I-refractory disease are suboptimal and do not represent definitive criteria to mandate whether ¹³¹I therapy should be recommended.

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