Deep Radiomic Analysis for Predicting Coronavirus Disease 2019 in Computerized Tomography and X-Ray Images

Abstract

This article proposes to encode the distribution of features learned from a convolutional neural network (CNN) using a Gaussian mixture model (GMM). These parametric features, called GMM-CNN, are derived from chest computed tomography (CT) and X-ray scans of patients with coronavirus disease 2019 (COVID-19). We use the proposed GMM-CNN features as input to a robust classifier based on random forests (RFs) to differentiate between COVID-19 and other pneumonia cases. Our experiments assess the advantage of GMM-CNN features compared with standard CNN classification on test images. Using an RF classifier (80% samples for training; 20% samples for testing), GMM-CNN features encoded with two mixture components provided a significantly better performance than standard CNN classification ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$p &lt; 0.05$ </tex-math></inline-formula> ). Specifically, our method achieved an accuracy in the range of 96.00%–96.70% and an area under the receiver operator characteristic (ROC) curve in the range of 99.29%–99.45%, with the best performance obtained by combining GMM-CNN features from both CT and X-ray images. Our results suggest that the proposed GMM-CNN features could improve the prediction of COVID-19 in chest CT and X-ray scans.

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