Laboratory-Scale AI: Open-Weight Models are Competitive with ChatGPT Even in Low-Resource Settings

Abstract

The rapid proliferation of generative AI has raised questions about the competitiveness of lower-parameter, locally tunable, open-weight models relative to high-parameter, API-guarded, closed-weight models in terms of performance, domain adaptation, cost, and generalization. Centering under-resourced yet risk-intolerant settings in government, research, and healthcare, we see for-profit closed-weight models as incompatible with requirements for transparency, privacy, adaptability, and standards of evidence. Yet the performance penalty in using open-weight models, especially in low-data and low-resource settings, is unclear.

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