Development and Evaluation of an Electronic Health Record–Derived Computable Phenotype to Identify Patients Undergoing Prostate Cancer Screening

Abstract

PURPOSE: for-cause diagnosis- or symptom-directed testing) are critical for reproducibility and comparison with prospective cohorts. METHODS: A cohort of patients who underwent PSA testing in a primary care setting at a large, tertiary health care system was identified. Gold-standard labels for screening versus not screening were created via a combination of clinical note text review and exclusionary diagnosis codes. Ten computable phenotype definitions were created by urology content experts and then evaluated for sensitivity, specificity, and positive predictive value (PPV) and negative predictive value against gold-standard labels. RESULTS: screening), 149 (50.3%) and 208 (58.6%) patients underwent screening. No single phenotype optimized both sensitivity and PPV, although a composite definition that included either (1) absence of symptoms or (2) presence of an encounter for screening code achieved a very high PPV of 0.99 (95% CI, 0.96 to 1.00) with a reasonable sensitivity of 0.82 (95% CI, 0.75 to 0.88). CONCLUSION: We identify code-based PSA screening phenotypes with a range of performance characteristics. Prevalence of for-cause diagnosis- and symptom-directed testing are significant and may contaminate cohorts not taking related codes into account.

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