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Figure 6 from Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group
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25
Autoren
2025
Jahr
Abstract
<p>Deep learning algorithms can predict event-free and overall survival from H&E histology alone. <b>A,</b> Schematic for training a convolutional neural network for survival. Patients with FN-RMS (<i>n</i> = 264) were partitioned into three groups based on EFS length to ensure even sampling and fed into a deep learning architecture with a Cox proportional hazard layer to assess risk. <b>B,</b> Kaplan–Meier curves for EFS based on COG clinical risk group assessment. <b>C,</b> Kaplan–Meier curves for event-free survival based on A.I. hazard prediction. <b>D,</b> Kaplan–Meier curves for OS based on COG clinical risk group assessment. <b>E,</b> Kaplan–Meier curves for OS based on the same A.I.-predicted risk grouping as in <b>C</b>.</p>
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Autoren
- David Milewski
- Hyun Jung
- G. Thomas Brown
- Yanling Liu
- Ben Somerville
- Curtis Lisle
- Marc Ladanyi
- Erin R. Rudzinski
- Hyoyoung Choo‐Wosoba
- Donald A. Barkauskas
- Tammy Lo
- David Hall
- Corinne M. Linardic
- Jun S. Wei
- Hsien-Chao Chou
- Stephen X. Skapek
- Rajkumar Venkatramani
- Peter K. Bode
- Seth M. Steinberg
- George Zaki
- Igor B. Kuznetsov
- Douglas S. Hawkins
- Jack F. Shern
- Jack Collins
- Javed Khan