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185eP A multi-module AI assistant for personalized breast cancer patient education and decision support

2025·0 Zitationen·ESMO Real World Data and Digital OncologyOpen Access
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0

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2

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2025

Jahr

Abstract

compared their mean estimated staining intensities.At the cell level, per-cell coexpression was estimated by locating nearest-neighbor cells in co-registered slides and averaging their staining intensities.Multi-resolution correlation analysis enabled quantitative evaluation of the new assay. Results:The results showed good concordancewith Pearson correlations of 0.81, 0.94 and 0.98 at the patch-level, between the estimated translucent chromogenic monoplex and triplex IHC staining intensities and the corresponding estimated DAB IHC staining intensities across the tested protein-chromogen combinations. Conclusions:The proposed co-registration approach enables quantitative assessment of biomarker measurement reliability by comparing translucent chromogenic multiplex assays with DAB monoplex assays.It also facilitates novel assay development by providing a systematic, quantitative framework for evaluating different chromogen combinations and staining sequences.

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AI in cancer detectionArtificial Intelligence in Healthcare and EducationExplainable Artificial Intelligence (XAI)
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