What makes a good clinical decision support system

Abstract

disease do occur, 10 and if the condition is suspected clinically, biopsy should still be carried out.A possible reason for negative antibody testing is IgA deficiency.This is more common in coeliac disease and since antiendomysial and anti-transglutaminase antibodies are normally measured as immunoglobulin A antibodies they will be absent in patients with IgA deficiency.Therefore in patients with IgA deficiency, IgG anti-endomysial and anti-transglutaminase antibodies need to be checked.Successful diagnosis of coeliac disease depends on a high index of suspicion, careful evaluation of investigations, and, where these are not clear, a willingness to review patients and make the diagnosis later in light of clinical progress and results of re-investigation.

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