Graph-theoretic metrics as predictors of CRS-R scores.

Abstract

<p>Panels A–D plot correlations between graph-theoretic metrics of alpha networks and behavioural CRS-R scores of individual patients. Red and blue circles indicate VS and MCS patients respectively. Filled circles indicate patients who followed command with fMRI tennis imagery. Robust linear regressions indicated by solid lines included all patients, whereas those indicated by dashed lines only included MCS patients. All metrics improved alongside progressive increase in CRS-R scores of MCS patients. Panels E, F and G plot alpha band networks of representative VS patients P1, P2 and P3, respectively. All 3 patients had the same CRS-R score, but only P3 showed evidence of command following. Compared to P1 and P2 (panels E and F), P3 also had remarkably well-preserved alpha network structure (panel G). Highlighted circles in panels A–D demonstrate that graph-theoretic metrics of P3's alpha network were exceptional outliers amongst the patient group, much more so than P3's delta/alpha power (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003887#pcbi-1003887-g001" target="_blank">figures 1E and F</a>).</p>

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