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How should we assess trustworthiness of randomized controlled trials?

2025·3 Zitationen·Journal of Clinical EpidemiologyOpen Access
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3

Zitationen

2

Autoren

2025

Jahr

Abstract

Readers of this journal will be well aware that many randomized controlled trials (RCTs) have serious methodological flaws, which undermine the credibility of their results. In addition, it is increasingly recognized that some trials are afflicted by problems of a different nature; they contain false data or results, and some have been entirely fabricated. These problematic studies may describe sound methods [1], which means that they are not flagged by common critical appraisal frameworks, such as risk of bias (RoB) tools [2,3].

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