The Use of Large Language Models in Ophthalmology: A Scoping Review on Current Use-Cases and Considerations for Future Works in This Field

Abstract

The advancement of generative artificial intelligence (AI) has resulted in its use permeating many areas of life. Amidst this eruption of scientific output, a wide range of research regarding the usage of Large Language Models (LLMs) in ophthalmology has emerged. In this study, we aim to map out the landscape of LLM applications in ophthalmology, and by consolidating the work carried out, we aim to produce a point of reference to guide the conduct of future works. Eight databases were searched for articles from 2019 to 2024. In total, 976 studies were screened, and a final 49 were included. The study designs and outcomes of these studies were analysed. The performance of LLMs was further analysed in the areas of exam taking and patient education, diagnostic capability, management capability, administration, inaccuracies, and harm. LLMs performed acceptably in most studies, even surpassing humans in some. Despite their relatively good performance, issues pertaining to study design, grading protocols, hallucinations, inaccuracies, and harm were found to be pervasive. LLMs have received considerable attention through their introduction to the public and have found potential applications in the field of medicine, and in particular, ophthalmology. However, using standardised evaluation frameworks and addressing gaps in the current literature when applying LLMs in ophthalmology is recommended through this review.

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