Artificial Intelligence in Medical Diagnostics: Foundations, Clinical Applications, and Future Directions

Abstract

Artificial intelligence (AI) is rapidly transforming medical diagnostics by allowing for early, accurate, and data-driven clinical decision-making. This review provides an overview of how machine learning (ML), deep learning, and emerging multimodal foundation models have been used in diagnostic procedures across imaging, pathology, molecular analysis, physiological monitoring, and electronic health record (EHR)-integrated decision-support systems. We have discussed the basic computational foundations of supervised, unsupervised, and reinforcement learning and have also shown the importance of data curation, validation metrics, interpretability methods, and feature engineering. The use of AI in many different applications has shown that it can find abnormalities and integrate some features from multi-omics and imaging, which has shown improvements in prognostic modeling. However, concerns about data heterogeneity, model drift, bias, and strict regulatory guidelines still remain and are yet to be addressed in this field. Looking forward, future advancements in federated learning, generative AI, and low-resource diagnostics will pave the way for adaptable and globally accessible AI-assisted diagnostics.

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