Comparison of GPT-5 and GPT-4o in Solving the Polish Centre for Medical Examinations (CEM) Gastroenterology Examination

Abstract

Both GPT-4o and GPT-5 exceeded the passing threshold for the CEM gastroenterology examination, demonstrating strong performance on a specialty-level medical assessment. Although overall accuracy was comparable, GPT-5 showed superior alignment between confidence and correctness, suggesting improved metacognitive reliability rather than a substantial gain in raw accuracy. These findings highlight the potential educational value of newer LLMs while underscoring important limitations, including the restricted sample size, exam-specific context, and lack of assessment of real-world clinical reasoning. Ethical considerations such as hallucinations, overconfidence, and inappropriate clinical reliance remain critical barriers to direct clinical deployment. Future research should focus on broader exam representativeness, task difficulty stratification, and controlled integration of LLMs into postgraduate medical education.

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