Artificial Intelligence in Medication Adherence: A National Assessment of Knowledge, Attitudes, and Perceptions Among Chronic Disease Patients in Jordan

Abstract

Zekrayat JH Merdas,1 Anas Abed,2 Zain Z Zakaria,3 Mohammad Abu Assab,4 Wael Abu Dayyih,5 Wasan A Almbaideen,5 Zainab Zakaraya,2 Mona Bustami6 1Pharmacy Department, College of Pharmacy, Amman Arab University, Amman, Jordan; 2Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan; 3Clinical Affairs Department, Qatar University, Doha, Qatar; 4Clinical Pharmacy Department, Faculty of Pharmacy, Zarqa University, Zarqa, Jordan; 5Faculty of Pharmacy, Mutah University, Alkarak, Jordan; 6Faculty of Pharmacy, University of Petra, Amman, JordanCorrespondence: Anas Abed, Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan, Email a.abed@ammanu.edu.joPurpose: To assess knowledge, attitudes, and perceptions toward AI-based medication adherence tools in a national cross-sectional survey among Jordanian adults with chronic diseases and to identify factors associated with favorable acceptance.Patients and Methods: A national cross-sectional online survey was conducted between January and July 2025 using convenience and snowball sampling and a self-developed, pilot-tested, and content-validated Arabic questionnaire. The questionnaire captured sociodemographic characteristics, digital literacy, chronic disease information, and KAP toward AI-based medication adherence tools. Knowledge was assessed using eight statements describing AI capabilities and rated on a five-point Likert scale, which were recoded dichotomously for scoring (score range 0– 8; ≥ 5 indicating good knowledge). Attitudes and perceptions were measured using five-point Likert scales (mean scores ≥ 3.5 indicating positive or high levels). Descriptive statistics, chi-square tests, multivariable logistic regression, sensitivity analyses, and polypharmacy subgroup analyses were performed to identify factors associated with favorable acceptance.Results: Among 552 participants (mean age 52.7 ± 12.6 years; 56.3% female), the most prevalent chronic diseases were hypertension (213, 38.6%) and diabetes mellitus (179, 32.4%), with 154 (27.9%) reporting polypharmacy (≥ 5 medications). 59.2% demonstrated good knowledge (mean score 5.3 ± 1.8). Moderately positive attitudes were observed in 48.6% (mean 3.6 ± 0.9), while 52.7% reported high perceptions (mean 3.7 ± 0.9). Strong support was reported for AI-based reminders (80%) and educational functions (76%), whereas endorsement of predictive features was lower (49– 58%). Major concerns included privacy (71%), technical reliability, and reduced human interaction. Chi-square tests showed significant associations with age and digital literacy (p < 0.001). Multivariable logistic regression confirmed that younger age, higher education, advanced digital literacy, and smartphone ownership independently predicted favorable KAP (p < 0.001). Polypharmacy was associated with greater receptivity in unadjusted analyses but was not an independent predictor after adjustment. Findings remained robust in sensitivity analyses.Conclusion: Jordanian patients with chronic diseases show moderate-to-good knowledge and cautiously positive attitudes toward AI-enabled medication adherence tools. Acceptance is shaped mainly by digital literacy and trust, underscoring the need for governance frameworks, clinician oversight, Arabic-language design, and targeted digital literacy initiatives to support equitable integration into national platforms such as Hakeem.Keywords: digital public health, medication adherence, digital health literacy, patient acceptance, health equity, chronic disease management

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