Coalition of explainable artificial intelligence and quantum computing in precision medicine

Abstract

This survey examines the convergence of Explainable Artificial Intelligence (XAI) and Quantum Computing (QC) toward precision medicine. We review developments from 2018 to 2025, summarizing quantum algorithms, quantum-machine-learning models and XAI techniques applied to drug discovery, disease diagnosis, patient monitoring and biomarker identification. We introduce a taxonomy of hybrid and quantum-explainable approaches, evaluate NISQ hardware and encoding constraints, and compare interpretability methods (SHAP, LIME, QSHAP, QLRP, TSBA). Two case studies (doxorubicin cardiotoxicity prediction and pre-symptomatic IBD flare forecasting) demonstrate hybrid variational-quantum pipelines wrapped with SHAP-based explanations. We identify practical barriers (noise, data encoding, regulation, privacy) and outline research directions to benchmark clinical quantum advantage and develop scalable, transparent QXAI frameworks. The survey aims to guide interdisciplinary efforts toward trustworthy, scalable quantum-enabled precision healthcare.

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